Antipas was an early bishop of Pergamum in Asia Minor and, by tradition, a disciple of the Apostle John the Theologian, who is said to have ordained him to the episcopate. He is distinguished as the only saint named directly by Christ in the Book of Revelation, where he is called a faithful witness slain in the city. The Church commemorates him as a hieromartyr on April 11.
According to the synaxarion tradition, Antipas led the Christian community of Pergamum during a period of persecution, generally placed in the reign of the emperor Nero (54-68), though some accounts assign his martyrdom instead to the reign of Domitian. When the pagan priests of the city demanded that he cease preaching Christ and offer sacrifice to the idols, he refused, professing his faith in the Lord Almighty.
The tradition relates that the enraged priests dragged Antipas to the temple of Artemis and cast him into a red-hot bronze bull, the heated vessel in which sacrifices to the idols were customarily consumed. As he died he is said to have prayed aloud, imploring God to receive his soul and to strengthen the faith of the Christians. His body was reported to have remained untouched by the fire, and Christians of Pergamum buried him in the city.
His tomb became a noted site of pilgrimage, remembered in the tradition as a source of miracles and of healing from various ailments. He is widely invoked for relief from toothache and diseases of the teeth, and on this account is regarded as a patron of dentists and of those who suffer dental afflictions.