See of Melitene
Melitene (modern Malatya in eastern Anatolia, Turkey) was a major Roman and Byzantine military and administrative center, established by the Romans in 72 AD as a base camp of the Legio XII Fulminata. Under Justinian I it became the capital of the province of Third Armenia, and the emperor Maurice raised it to capital of Armenia Prima in 591, within Dometian's own episcopate.
The city held shrines to martyrs, including the widely venerated local saint Polyeuctus. Its strategic location and ecclesiastical standing made it a crucial center for Byzantine-Armenian religious and political affairs, which helps explain why its bishop would be entrusted with diplomatic missions to Persia.